Lithium-induced EEG changes in patients with affective disorders.
نویسندگان
چکیده
In 12 patients with affective disorders (ICD-10: F31, F32, F33), EEGs were recorded before and after 4.4 months of lithium treatment. Effects of lithium on the EEG were analyzed by power spectral analysis controlled for vigilance. We found (1) an increase in relative power in both delta and theta band which was related to the lithium plasma level, (2) a decrease in relative alpha power especially at occipital leads and (3) a reduction of the dominant alpha frequency. The changes in relative power were more pronounced in the right hemisphere, which is in contrast to the hypothesis of a site-specific localization of lithium effects only in left anterior regions.
منابع مشابه
Nonconvulsive status epilepticus and Creutzfeldt–Jakob-like EEG changes in a case of lithium toxicity
We report a case of a 63-year-old lady with bipolar affective disorder on lithium who was brought to our emergency center in a comatose state. Neurologically, the patient was comatose and had generalized hypotonia and hyporeflexia. Lithium toxicity was considered. Laboratory examinations revealed leukocytosis, normal blood sugar, blood level of lithium was 4.7 mEq/L and she had renal dysfunctio...
متن کاملBrain oscillations in bipolar disorder and lithium-induced changes
Electroencephalography (EEG) studies in patients with bipolar disorder have revealed lower amplitudes in brain oscillations. The aim of this review is to describe lithium-induced EEG changes in bipolar disorder and to discuss potential underlying factors. A literature survey about lithium-induced EEG changes in bipolar disorder was performed. Lithium consistently enhances magnitudes of brain os...
متن کاملManaging the risk of lithium-induced nephropathy in the long-term treatment of patients with recurrent affective disorders
Lithium has been the most effective psychopharmacological drug in the long-term treatment of patients with recurrent unipolar and bipolar affective illness. As a result of its widespread and longtime use in patients with recurrent affective disorders, psychiatrists have become increasingly aware of the whole spectrum of lithium's potential side effects. One of the side effects associated with i...
متن کاملTeaching neuroimages: reversible paradoxical lithium neurotoxicity.
A 33-year-old man with bipolar affective disorder presented with acute onset of rigidity, tremors, and confusion. He had been taking oral lithium (1,200 mg daily) for the past 2 months. Baseline blood, EEG, and CSF analyses were normal. Serum lithium level was 0.67 mEq/L (0.3–1.3). GadoliniumMRI brain showed multiple bilateral symmetric T2-weighted hyperintensities (figure, A–C). On suspicion o...
متن کاملA study on striatal local electrical potential changes in an animal model of Parkinson's disease
Parkinson’s disease (PD) is a neurodegenerative disorder that does not develop spontaneously in some animal species. PD can be induced experimentally in some laboratory animals including mouse, rat and horse. Globus pallidus (GP) and substantia nigra pars compacta (SNc) are damaged in patients with PD. The hallmark of PD is a progressive impaired control of movement, an alteration of autonomic ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Neuropsychobiology
دوره 42 Suppl 1 شماره
صفحات -
تاریخ انتشار 2000